Important Safety Information for Oral Microdose

What is Oral Microdose?

Oral Microdose is a sublingual (under-the-tongue) formulation of low-dose semaglutide designed for metabolic support and longevity benefits. This needle-free option delivers semaglutide through the tissues under your tongue for direct absorption into the bloodstream. Microdosing focuses on activating beneficial GLP-1 pathways without the intense effects of standard weight loss dosing.

Important Warning: Thyroid Tumor Risk

In animal studies, semaglutide has caused thyroid C-cell tumors. Whether this applies to humans is not yet established. Do not use oral microdose semaglutide if you or a family member has a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

Contact your healthcare provider if you notice:

• A lump in your neck
• Persistent hoarseness
• Difficulty swallowing
• Unexplained shortness of breath

Who Should Not Use Oral Microdose?

This medication is contraindicated if you:

• Have a personal or family history of medullary thyroid carcinoma
• Have Multiple Endocrine Neoplasia syndrome type 2
• Have had a severe allergic reaction to semaglutide
• Have active or recurrent pancreatitis
• Are pregnant, planning pregnancy, or breastfeeding

Warnings and Precautions

1. PancreatitisEven at low doses, semaglutide may cause inflammation of the pancreas. Seek immediate medical care if you develop severe abdominal pain radiating to your back. Do not restart therapy if pancreatitis is confirmed.

2. Eye ComplicationsPatients with diabetic retinopathy should be monitored closely. Rapid blood sugar improvements have been associated with temporary worsening of eye disease.

3. Blood Sugar EffectsIf you take diabetes medications, particularly insulin or sulfonylureas, be aware of potential hypoglycemia risk. Your provider may need to adjust your other medication doses.

4. Kidney HealthDehydration from any cause can affect kidney function. Maintain good hydration and report persistent GI symptoms to your provider.

5. Gallbladder DiseaseGLP-1 medications may increase gallbladder problems. Seek care for sudden upper abdominal pain, especially on the right side.

6. Allergic ReactionsSerious hypersensitivity reactions are possible. Stop taking oral microdose and seek emergency care if you experience severe rash, swelling, or difficulty breathing.

Common Side Effects

Side effects at microdose levels are generally mild:

• Mild nausea
• Slight taste changes (due to sublingual administration)
• Mild stomach discomfort
• Headache
• Fatigue

These effects typically improve as your body adjusts.

Pregnancy and Breastfeeding

Pregnancy: Do not use during pregnancy. Discontinue at least 2 months before attempting to conceive.

Breastfeeding: Safety during breastfeeding is not established. Discuss options with your healthcare provider.

How to Take Oral Microdose

• Place prescribed dose under your tongue using the provided syringe
• Hold under tongue for at least 90 seconds before swallowing
• Take on an empty stomach
• Do not eat or drink (except water) for 30 minutes after your dose
• Take at the same time each day for consistent results
• Follow your provider's dosing instructions exactly

Storage

• Store at room temperature away from direct sunlight and heat
• Keep container tightly closed
• Do not freeze
• Keep out of reach of children

Drug Interactions

Inform your provider about all medications, especially:

• Insulin and diabetes medications
• Oral contraceptives
• Blood thinners
• Thyroid medications
• Other GLP-1 medications (do not combine)

When to Seek Medical Attention

Contact your provider or seek emergency care for:

• Severe or persistent stomach pain
• Signs of allergic reaction
• Severe dehydration symptoms
• Vision changes
• Any symptoms that concern you

This safety information is not comprehensive. Consult your healthcare provider for complete guidance.